Aliases &
Descriptions
for KRT86 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
and/or 9miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| keratin 861 2 | | FLJ251762 | | KRTHB62 3 5 | | Hb12 | | MNX1 2 | | KRTHB12 | | keratin, hair, basic, 6 (monilethrix)1 2 | | hHb62 | | Hair keratin K2.112 3 | | hard keratin, type II, 62 | | Type II hair keratin Hb62 3 | | keratin protein HB62 | | Type-II keratin Kb262 3 | | keratin, type II cuticular Hb62 | | K862 3 | | keratin-862 | | HB62 5 | | Keratin-863 | | Hb61 | | |
Export aliases for KRT86 gene to outside databasesPrevious GC identifers: GC12P050982 GC12P049730 |
Summaries
for KRT86 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT86:
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basicprotein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered ina region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. Onesubfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includesKRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patientswith a rare dominant hair disease, monilethrix. (provided by RefSeq)
Gene Wiki entry for KRT86 |
Genomic Views
for KRT86 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 61),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT86 gene promoter:
NRSF form 2 NRSF form 1 Max1 c-Myc USF1 Arnt ER-alpha Bach2 CUTL1 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT86
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13KRT86 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P052695: view genomic region
(about GC identifiers)
Start:
|
52,695,649 bp from pter |
End:
|
52,702,947 bp from pter |
Size:
|
7,299 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for KRT86 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
Specific Peptides from DME,
Protein expression images from SPIRE MOPED,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
EMD Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 May 2011 and
Entrez Gene,
Antibodies by
EMD Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KRT86_HUMAN, O43790 (See
protein sequence)Recommended Name: Keratin, type II cuticular Hb6 Size: 486 amino acids; 53501 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: P78387Explore the universe of human proteins at neXtProt for KRT86: NX_O43790
Post-translational modifications:
View phosphorylation sites using PhosphoSite2Protein expression data from SPIRE
MOPED: 
About this image
REFSEQ proteins: NP_002275.1
ENSEMBL proteins: ENSP00000293525
Human Recombinant Proteins
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
NAS | -- | | GO:0045095 | keratin filament |
IEA | -- |
About this table
KRT86 for ontologies About GeneDecksing
Antibodies for KRT86:
Assays for KRT86: |
Protein
Domains/
Families
for KRT86 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT86 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43790ProtoNet protein and cluster: O43790 2 Blocks protein families: IPB001664 Intermediate filament protein IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: KRT86_HUMAN, O43790Similarity: Belongs to the intermediate filament family |
Gene Function
for KRT86 gene
(According to 1UniProtKB,
Genatlas,
IUBMB, and/or
2DME,
Animal models from MGI May 11 2011,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
EMD Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Gene Editing from Sigma-Aldrich,
Clones from EMD Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 May 2011 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
NAS | -- |
About this table
KRT86 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRT86 gene
(Pathways according to
EMD Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT,
3I2D,and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 May 2011 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for KRT86
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT86
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007010 | cytoskeleton organization |
NAS | -- |
About this table
KRT86 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT86 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience,
HMDB, and/or
Novoseek and Drugs according to
DrugBank,
Enzo Life Sciences
PharmGKB, and/or
TarThera)
About This Section
|
KRT86 for compounds About GeneDecksing
 Browse Tocris compounds for KRT86
2  Novoseek chemical compound relationships for KRT86 gene
About this table
|
Transcripts
for KRT86 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 229 Homo sapiens; Feb 23 2011) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KRT86 gene: NM_002284.3 Additional cDNA sequence: AK292237.1 AK297794.1 BC069585.1 X99142.1 5 DOTS entries: DT.95069074 DT.405699 DT.100645926 DT.40271285 DT.97770268 24/762 AceView cDNA sequences (see all 762): AA385463 AU104593 AA372031 BM980539 AU155447 BU956135 BM850512 BM142377 BQ691665 AI368926 BQ380667 AW627487 BX480249 T95050 BM834695 AW630494 AI927832 AW627469 BQ350308 BE740515 BI490003 BI819350 CB853835 CN483322
 highest scoring ESTs for KRT86:X99142 AA397519 AA639491 AI142699 AI368926 BC069585 BG186568 BG203083 BG206223 BG216771 Unigene Cluster for KRT86: Keratin 86 Hs.278658 [show with all ESTs]Unigene Representative Sequence: NM_002284
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000293525(uc009zmg.1 uc001sad.1)
|
Expression
for KRT86 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 229 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences, PCR Arrays from
SABiosciences
)
About This Section
| KRT86 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching KRT86 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32329_at2, 3
|
U95-A |
2 |
0.62 |
0.54 |
1.00 |
1.00 |
X99142 |
1.00 |
1.00 |
1.00 |
1 |
| 215189_at2, 3
|
U133-A |
2 |
0.73 |
0.75 |
-- |
-- |
X99142 |
1.00 |
1.00 |
1.00 |
1 |
| 215189_at2
|
U133Plus2 |
2 |
0.73 |
0.75 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KRT86 for expression About GeneDecksing
mRNA expression data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
See Protein Expression from SPIRE MOPED
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.278658
UniProtKB/Swiss-Prot: KRT86_HUMAN, O43790Tissue specificity: Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up,ending in the keratogeneous zone
SABiosciences Custom PCR Arrays for KRT86
|
Orthologs
for KRT86 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI May 11 2011,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KRT86 gene from 4/12 species (see all 12) 
About this table
ENSEMBL Gene Tree for KRT86 (if available) |
Paralogs
for KRT86 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KRT86 gene
- KRT82 KRT812 KRT852 KRT8P112 KRT72 KRT832 KRT822 KRT842
KRT86 for paralogs About GeneDecksing
|
Genomic Variants
for KRT86 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from Qiagen,
Cancer Mutation PCR Arrays and Assays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KRT86 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for KRT86
7 CNVs: 53570 2984 9695 8730 3889 66223 23297
Human Gene Mutation Database (HGMD): KRT86
| | QIAGEN SeqTarget long-range PCR primers for resequencing KRT86 |
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
for KRT86 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
TarThera,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT86 for disorders About GeneDecksing
OMIM: 601928 disorders: 158000 UniProtKB/Swiss-Prot: KRT86_HUMAN, O43790
Defects in KRT86 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hairdisorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes ofnormal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp isinvolved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected
3 Novoseek disease relationships for KRT86 gene
About this table
Genetic Association Database (GAD): KRT86
Human Genome Epidemiology (HuGE) Navigator: KRT86 (1 document)
Export disorders for KRT86 gene to outside databases
|
Publications
for KRT86 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/38 PubMed articles for KRT86 gene, integrated from 7 sources (see all 38):
(articles sorted by number of sources associating them with KRT86)- Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype. (PubMed id 10504448)1, 2, 7 Korge B.P....Munro C.S. (1999)
- Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix. (PubMed id 10594761)1, 2, 7 Pearce E.G.... Bowden P.E. (1999)
- Sequences and differential expression of three novel human type-II hair keratins. (PubMed id 9084137)1, 2, 7 Rogers M.A....Schweizer J. (1997)
- Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6. (PubMed id 10469314)1, 2, 7 Winter H.... Schweizer J. (1999)
- Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PubMed id 9457912)1, 2, 7 Bowden P.E.... Hodgins M.B. (1998)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A novel promoter polymorphism (-71C>T) in KRTHB6 gene in Indian population. (PubMed id 15183744)1, 4 Bairwa N.K.... Bamezai R. (2004)
- A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. (PubMed id 9402962)1, 2 Winter H....Schweizer J. (1997)
- [Analysis of human hair basic keratin 6 gene mutation in a Chinese Han family with monilethrix] (PubMed id 18393232)1, 7 Feng A.P....Yang T. (2008)
|
External Searches for KRT86 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT86 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT86 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT86 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Human Intermediate Filament Mutation Database | http://www.interfil.org | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT86 |
|
| | |
About This Section
| Patent Information for KRT86 gene:
Search GeneIP for patents involving KRT86
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT86 gene(Antibodies, recombinant proteins, and assays by EMD Millipore, Sigma-Aldrich, R&D Systems, OriGene, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Epitomics, ProSpec, Uscn, Gene Editing from Sigma-Aldrich,
Clones available from EMD Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for KRT86 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for KRT86 |
| |
|
|
